Search results for " liver-related events"

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A Genetic and Metabolic Staging System for Predicting the Outcome of Nonalcoholic Fatty Liver Disease

2022

Nonalcoholic fatty liver disease (NAFLD) is an emerging cause of liver-related events (LREs). Here, we have assessed the ability of a composite score based on clinical features, metabolic comorbidities, and genetic variants to predict LREs. A total of 546 consecutive patients with NAFLD were recruited and stratified according to the fibrosis-4 (FIB-4) index. LREs were defined as occurrence of hepatocellular carcinoma or hepatic decompensation. Cox regression multivariate analysis was used to identify baseline variables associated with LREs. The UK Biobank was used as the validation cohort, and severe liver disease (incidence of cirrhosis, decompensated liver disease, hepatocellular carcinom…

Liver CirrhosisCarcinoma HepatocellularHepatologyNon-alcoholic Fatty Liver DiseaseLiver NeoplasmsHumansNAFLD liver decompensation liver fibrosis cirrhosis liver-related events hepatocellular carcinoma
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A cholestatic pattern predicts major liver-related outcomes in patients with non-alcoholic fatty liver disease

2022

NAFLD patients usually have an increase in AST/ALT levels, but cholestasis can also be observed. We aimed to assess in subjects with NAFLD the impact of the (cholestatic) C pattern on the likelihood of developing major liver-related outcomes (MALO).

Liver CirrhosisCholestasisHepatologyBiopsyNASHNAFLD Cholestasis Cirrhosis Fibrosis Hepatocellular carcinoma Liver-related events Liver decompensation610 Medicine & healthMiddle AgedFibrosisLiverCirrhosisNon-alcoholic Fatty Liver DiseaseNAFLDHumans610 Medicine & health
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